170例H月sAg阳性孕妇所生新生儿乙肝免疫阻断

王佩琼，陈弘星

（陕西省宝鸡市凤翔县医院保健科，陕西宝鸡，721400）

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摘要：

目的 探讨H月sAg阳性孕妇所生新生儿乙肝免疫阻断及感染情况，为母婴阻断提供依据。方法 抽取于我院生产的H月sAg阳性孕妇共170例，将接受被动免疫(H月lg)的72例孕妇作为观察组，未接受H月lg 的98例孕妇作为对照组。观察组自孕21周始，每4周注射1次乙肝免疫球蛋白，200 IU/次，直到分娩。两组新生儿在出生24h采集脐静脉血进行乙肝血清标志物及HBV定量测定。结果 观察组新生儿出生24h H月sAg阳性率、表面抗体保护率均优于对照组，差异有统计学差异(P＜0.05);母乳喂养的93例新生儿中无H月sAg阳性，但H月sAb阳性率明显高于人工喂养，差异有统计学意义(P＜0.05)。结论 母亲H月sAg阳性的新生儿H月sAg阳性率较高，但孕期接受H月lg 可大大降低新生儿H月sAg 阳性率，增加H月sAb抗体保护率。HBsAg阳性母亲的儿童采取乙肝疫苗联合乙肝免疫球蛋白预防接种进行传播阻断，其阻断成功率相对较高。

关键词：母亲H月sAg阳性；新生儿；乙肝免疫阻断

中图分类号：R714.25文献标志码：A文章编号：2096-1413(2017)06-0133-02

Analysis of hepatitis B immune blocking and infection of newborns in 170 cases of H月sAg positive pregnant women

WANG Pei-qiong, CHEN Hong-xing

(Department of Health, Fengxiang County Hospital, Baoji 721400, China)

ABSTRACT: Objective To investigate B immune blocking and infection of newborns in 170 cases of H月sAg positive pregnant women, and to provide evidence for maternal and infant block. Methods A total of 170 H月sAg positive pregnant women in our hospital were selected, of which 72 cases received passive immunization (H月lg) were selected as the observation group, 98 cases did not receive H月lg were selected as the control group. The observation group had injection of hepatitis B immune globulin every 4 weeks since 21 weeks before pregnancy, 200 IU/time until delivery. The hepatitis B serum markers and quantitative determination of HBV of newborns in the 24 h after birth in the two groups were detected by collecting umbilical vein blood. Results The positive rate of H月sAg and the protective rate of surface antibody of newborns in 24 h after birth in the observation group were better than those in the control group (P<0.05); there was no HBsAg positive cases in 93 newborns who had breastfeeding, but their positive rate of HBsAb was significantly higher than that of artificial feeding (P约0.05). Conclusion The H月sAg positive rate of newborns in H月sAg positive mother is higher,but for pregnant women, receiving H月lg during pregnancy can greatly decrease the positive rate of H月sAg of newborns, and increase the protection rate of H月sAb antibody. Children who have HBsAg positive mothers can have hepatitis B vaccine combined with hepatitis B immunoglobulin vaccination to block the transmission, and the blocking success rate is relatively high.

KEYWORDS: maternal H月sAg positive; newborn; hepatitis B immune blockade

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