地屈孕酮与黄体酮治疗先兆流产疗效观察

刘红梅，朱华

（陕西省渭南市大荔县医院妇产科，陕西 渭南，715100）

浏览次数：187次 下载次数：420次

摘要：

目的 对比地屈孕酮与黄体酮用于治疗先兆流产的临床效果。方法 选择我院收治的150 例先兆流产患者为研究对象， 其中75 例患者采用地屈孕酮治疗，设定为地屈孕酮组，其余75例患者采用黄体酮治疗，设定为黄体酮组，对比两组患者的 临床治疗效果。结果 两组患者的腰酸缓解时间、腹痛缓解时间、止血时间比较，差异无统计学意义（P>0.05）；治疗前，两组患 者的人绒毛膜促性腺激素（HCG）、雌二醇（E2）水平比较，差异无统计学意义（P>0.05）；治疗后，两组患者的HCG、E2水平均高 于治疗前（P<0.05）；两组患者的保胎成功率比较，差异无统计学意义（P>0.05）；地屈孕酮组不良反应发生率为22.67%，明显低于黄体酮组的42.67%（P<0.05）。结论 地屈孕酮与黄体酮用于治疗先兆流产临床效果显著，保胎效果良好，地屈孕酮不良反应发生率更低，临床应用价值更高。

关键词：地屈孕酮；黄体酮；先兆流产

中图分类号：R741.21文献标志码：A文章编号：2096-1413(2017)09-0109-02

Clinical effect observation of dydrogesterone and progesterone in the treatment of patients with threatened abortion
LIU Hong-mei, Zhu Hua
(Department of Obstetrics and Gynecology, Dali County Hospital, Weinan 715100, China)

ABSTRACT: Objective To compare the clinical effect of dydrogesterone and progesterone in the treatment of patients with threatened abortion. Methods One hundred and fifty cases of patients with threatened abortion admitted in our hospital were selected as the study objects. Seventy-five cases of patients were treated with dydrogesterone, which were chosen as the dydrogesterone group; the other 75 cases of patients accepted progesterone, which were chosen as the progesterone group. The clinical effects of two groups were compared. Results There were no significant differences on lumbar acid remission time, abdominal pain relief time and bleeding time of two groups (P>0.05). Before treatment, there were no significant differences on the levels of HCG and E2 of two groups (P>0.05). After treatment, the levels of HCG and E2 of two groups were better than those before the treatment (P<0.05); There was no significant difference on success rate of tocolytic of two groups (P>0.05). The incidence rate of adverse reactions of the dydrogesterone group was 22.67%, which was lower than 42.67% of the progesterone group (P<0.05). Conclusion Dydrogesterone and progesterone in the treatment of patients with threatened abortion have significant clinical effect, the tocolytic effect is good, but dydrogesterone has fewer adverse reactions and higher clinical value.

KEYWORDS: dydrogestrone; progesterone; threatened abortion

参考文献：
[1] 高群,施文银,王海莲,等.地屈孕酮治疗早期先兆流产的临床观察 [J].临床合理用药杂志,2012,5(20):77-78.

[2] 张玲,申爱方,由卫芝,等.早期先兆流产保胎价值评估及个性化治疗的临床研究[J].中国实用医药,2012,7(25):61-62.
[3] 卫爱民.地屈孕酮治疗先兆流产的Meta分析[J].山东医药,2013,53(11):61-62.
[4] 骆小英.地屈孕酮与黄体酮治疗先兆流产的临床疗效分析[J].中国妇幼保健,2013,28(2):343-345.
[5] 姚倩,吴艳.黄体功能不全性不孕症的神经内分泌免疫机制及治疗进展[J].中国药物经济学,2013,18(9):34-40.
[6] 官清,岳建宏.地屈孕酮治疗先兆流产92例疗效观察[J].陕西医学杂志,2013,42(9):1266.
[7] 王丽君,胡晨,吴江平.黄体功能不全先兆流产的治疗及血清孕酮值与治疗结局的相关性分析[J].现代妇产科进展,2015,24(1):40-43.
[8] 刘丽霞,姚志芹,王秀琴.黄体酮个体化治疗复发性流产的临床研究[J].中国医药科学,2013,3(20):197-198.