头孢哌酮舒巴坦钠与环丙沙星治疗老年支气管扩张急性加重患者临床效果比较

康建军，高仑，孙秀娥

（陕西省榆林市第一医院呼吸内科，陕西 榆林，718000）

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摘要：

目的 对头孢哌酮舒巴坦钠与环丙沙星治疗老年支气管扩张急性加重患者的临床效果进行探究。方法 选取我院收治的100例老年支气管扩张急性加重患者作为研究对象，用随机数字表法分为观察组和对照组，各50例。观察组患者给予头 孢哌酮舒巴坦钠治疗，对照组患者给予环丙沙星治疗，观察对比两组患者临床治疗效果、不良反应发生情况、细菌分布及细 菌清除情况。结果 两组的治疗总有效率、不良反应发生率（皮疹、失眠、腹痛及恶心呕吐）比较无明显差异（P>0.05）；本研究共 检出60株病原菌，观察组检出31株，对照组检出29株。观察组痰液病原菌总清除率、肺炎克雷伯菌清除率高于对照组（P<0.05）；两组的流感嗜血杆菌、铜绿假单胞菌清除率无明显差异（P>0.05）。结论 对老年支气管扩张急性加重患者采用头孢哌酮舒巴坦钠和环丙沙星进行治疗，均具有较少的不良反应，但头孢哌酮舒巴坦具有较高的细菌清除率，值得应用。

关键词：老年支气管扩张急性加重患者；头孢哌酮舒巴坦；环丙沙星

中图分类号：R562.2 文献标志码：A文章编号：2096-1413(2017)13-0031-02

Comparison of cefoperazone sulbactam and ciprofloxacin in elderly patients with acute exacerbation of bronchiectasis
KANG Jian-jun, GAO Lun, SUN Xiu-e
(Department of Respiratory Medicine, the First Hospital of Yulin City, Yulin 718000, China)

ABSTRACT: Objective To explore the clinical effect of cefoperazone sulbactam and ciprofloxacin in elderly patients with acute exacerbation of bronchial dilatation. Methods One hundred cases of elderly patients with acute bronchiectasis in our hospital were selected as the study objects and randomly divided into observation group and control group (n=44) with digital table method. The control group was treated with cefoperazone sulbactam, and the control group was treated with ciprofloxacin. The total effective rate, incidence rate of the adverse reaction, distribution of bacteria and bacteria clearance rate were compared in the two groups. Results There were no significant difference in the total effective rate and incidence rate of adverse reactions (skin rash, insomnia, abdominal pain and nausea and vomiting) (P>0.05). In this study, a total of 60 pathogens were detected, 31 strains were detected in the observation group and 29 strains in the control group. The total clearance rate of sputum pathogens, the clearance rate of klebsiella pneumoniae in the observation group were higher than those in the control group (P<0.05). There was no significant difference in the clearance rate of Haemophilus influenzae and pseudomonas aeruginosa in the two groups (P>0.05). Conclusion Cefoperazone sulbactam and ciprofloxacin in the treatment of elderly patients with acute exacerbation of bronchial dilatation have low incidence of adverse reactions, but cefoperazone sulbactam has a higher bacterial clearance rate, it is worthy of application.
KEYWORDS: acute exacerbation of bronchiectasis in elderly patients; cefoperazone sulbactam; ciprofloxacin

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