依折麦布联合瑞舒伐他汀对2型糖尿病合并高脂血症患者血脂水平的影响

程艳荣，王琳，张麦浪

（西安高新医院内分泌科，陕西 西安，710077）

浏览次数：87次 下载次数：360次

摘要：

目的 观察依折麦布联合瑞舒伐他汀对2 型糖尿病合并高脂血症患者血脂水平的影响。方法 选取我院收治的2型糖尿病合并高脂血症患者94 例，随机分为对照组及观察组，各47 例。对照组患者给予常规治疗及瑞舒伐他汀治疗，观察组在此基础上加用依折麦布治疗。观察两组患者的血脂水平、不良反应发生情况及临床疗效。结果 治疗后，两组患者血脂水平均明显优于治疗前，且观察组血脂水平均优于对照组（P<0.05）；观察组患者不良反应总发生率为4.26%，明显低于对照组的 17.02%（P<0.05）；观察组治疗总有效率为97.87%，显著高于对照组的82.98%（P<0.05）。结论 对2型糖尿病合并高脂血症患者给予瑞舒伐他汀联合依折麦布进行治疗，患者治疗后血脂水平改善明显，服药不良反应发生情况少，用药安全性好，临床疗效显著。

关键词：依折麦布；瑞舒伐他汀；2 型糖尿病；高脂血症；血脂水平

中图分类号：R587.1；R589.2 文献标志码：A文章编号：2096-1413(2017)19-0013-02

Effect of ezetimibe combined with rosuvastatin on the blood lipid levels in patients with type 2 diabetes

mellitus and hyperlipidemia
CHENG Yan-rong, WANG Lin, ZHANG Mai-lang
(Department of Endocrinology, Xi``an Gaoxin Hospital, Xi``an 710077, China)

ABSTRACT: Objective To observe the effect of ezetimibe combined with rosuvastatin on the blood lipid levels in patients with type 2 diabetes mellitus and hyperlipidemia. Methods Ninety-four patients with type 2 diabetes mellitus and hyperlipidemia admitted in our hospital were randomly divided into control group and observation group, with 47 cases in each group. The control group was given conventional treatment and rosuvastatin, and the observation group was treated with ezetimibe on the basis of the control group. The blood lipid levels, adverse reactions and clinical effects of the two groups were observed. Results After treatment, the blood lipid levels of the two groups were better than those before treatment, and those of the observation group were better than the control group (P<0.05). The total incidence rate of adverse reactions in the observation group was 4.26%, which was lower than 17.02% in the control group (P<0.05). The total effective rate of the observation group was 97.87%, which was significantly higher than 82.98% of the control group (P<0.05). Conclusion Rosuvastatin combined with ezetimibe for patients with type 2 diabetes mellitus and hyperlipidemia can significantly improve blood lipid level, and has less drug adverse reactions and good drug safety, which has remarkably clinical efficacy.

KEYWORDS: ezetimibe; rosuvastatin; type 2 diabetes mellitus; hyperlipidemia; blood lipid level

参考文献：
[1] 李剑,闫双通,龚燕平,等.依折麦布联合瑞舒伐他汀治疗2型糖尿病合并高脂血症的临床效果[J].中国医药,2016,11(6):821-824.
[2] 宗雪峰,李为东,路雯,等.瑞舒伐他汀联合依折麦布干预急性心肌梗死患者血脂水平的临床研究[J].徐州医学院学报,2013,33(12):833-835.
[3] 李丽燕,李雷,杨荣礼.依折麦布联合瑞舒伐他汀治疗高脂血症疗效观察[J].蚌埠医学院学报,2014,39(4):451-453.
[4] 陈红霞,刘如泉,黄秋菊,等.依折麦布联合瑞舒伐他汀治疗老年糖尿病并发高脂血症38 例[J].医药导报,2014,33(2):216-218.
[5] 龙飞飞,王杨,姜明珠,等.依折麦布辛伐他汀片短期内降脂疗效[J].中国老年学杂志,2014,34(18):5278-5279.
[6] 王媛媛,吴丹静,李艳伟,等.瑞舒伐他汀联合依折麦布治疗老年糖尿病并发高脂血症的临床疗效[J].中国老年学杂志,2016,36(6):1358-1359.
[7] 丁晓虎,李彩云,丁峰.依折麦布联合瑞舒伐他汀治疗冠心病患者血脂异常的疗效与安全性的Meta 分析[J].江苏医药,2016,42(9):1042-1044.