异丙托溴铵联合沙丁胺醇及布地奈德雾化吸入治疗小儿毛细支气管炎疗效观察

周小兰，周银，朱保卫，任建红

（安康市人民医院儿科，陕西 安康，725000）

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摘要：

目的 研究异丙托溴铵联合沙丁胺醇、布地奈德雾化吸入治疗小儿毛细支气管炎的效果。方法 选取2014 年1 月至2016 年12 月我院收治的毛细支气管炎患儿62例，随机分成对照组和观察组，各31例。对照组给予常规对症治疗，观察组在此基础上加用异丙托溴铵、沙丁胺醇、布地奈德雾化吸入，对比两组患儿的治疗总有效率、临床症状缓解时间、免疫功能情 况。结果 观察组患儿的治疗总有效率为100.00%，明显高于对照组的80.65%（P<0.05）；观察组患儿的咳嗽缓解时间、气喘缓解时间、肺音消失时间均少于对照组（P<0.05）；治疗前，两组患儿CD4+、CD8+、IgE 比较，无显著差异（P>0.05）；治疗7 d 后，两组患儿的CD4+、CD8+、IgE 均明显改善，且观察组改善优于对照组（P<0.05）。结论 采用异丙托溴铵、沙丁胺醇、布地奈德雾化吸入治疗小儿毛细支气管炎，效果确切，有助于缓解患儿临床症状，改善免疫系统功能，促进患儿康复。

关键词：异丙托溴铵；沙丁胺醇；布地奈德；雾化吸入；毛细支气管炎；免疫功能

中图分类号：R725.6文献标志码：A文章编号：2096-1413(2017)20-0084-02

Effect of ipratropium bromide combined with salbutamol and budesonide inhalation in the treatment

of bronchiolitis in children
ZHOU Xiao-lan, ZHOU Yin, ZHU Bao-wei, REN Jian-hong
(Department of Paediatrics, Ankang People``s Hospital, Ankang 725000, China)

ABSTRACT: Objective To study the effect of ipratropiu m bromide combined with salbutamol and budesonide in the treatment of bronchiolitis in children. Methods Sixty -two cases of children with bronchiolitis from January 2014 to December 2016 in our hospital were selected and randomly divided into control group and observation group, with 31 cases in each group. The control group was given conventional treatment, while the observation group was treated with ipratropium bromide combined with salbutamol and budesonide by aerosol inhalation on the basis of the control group. The total effective rate, clinical symptoms remission time and immune function index between the two groups were compared. Results The total effective rate of the observation group was 100.00%, which was higher than 80.65% of the control group (P<0.05). The cough relief time, asthma remission time, pulmonary rales disappeared time in the observation group were less than those in the control group (P<0.05). Before treatment, there were no significant differences in CD4+, CD8+, IgE between the two groups (P>0.05). After 7 days treatment, the CD4+, CD8+, IgE in the two groups significantly improved, and the improvement degree of the observation group was better than that of the control group (P<0.05). Conclusion The effect of ipratropium bromide combined with salbutamol and budesonide in the treatment of bronchiolitis in children is significant. It helps to relieve clinical symptoms, improve immune function and promote the rehabilitation of children.
KEYWORDS: ipratropium bromide; salbutamol; budesonide; aerosol inhalation; bronchiolitis; immune function

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