血清脂蛋白（a）与C 反应蛋白在尿毒症血液透析患者中的变化及意义

高黝，何宝明，李玲贤

（陕西省汉中市中心医院检验科，陕西 汉中，723000）

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摘要：

目的 探讨尿毒症血液透析患者治疗中血清脂蛋白（a）与C 反应蛋白的变化及意义。方法 选取2015年4月至2016年 4月本院收治的尿毒症血液透析患者52例为研究组；选取同期本院体检的52名健康人为对照组。比较两组患者血清脂蛋白（a）[Lp（a）]、C 反应蛋白（CRP）、尿素氮和血清肌酐检测结果。结果 研究组透析后血清Lp（a）、CRP、尿素氮、血清肌酐水平均高于对照组，且研究组透析后血清Lp（a）与CRP水平均明显低于透析前（P<0.05）；研究组血清Lp（a）与CRP 呈现正相关 （P<0.05），与血肌酐、尿素氮无相关性（P>0.05）。结论 应加强尿毒症血液透析患者血清Lp（a）与CRP水平检测，尽早采取积 极措施进行治疗，以减少心脑血管事件的发生。

关键词：尿毒症；血液透析；血清脂蛋白（a）；C 反应蛋白

中图分类号：R692.5文献标志码：A文章编号：2096-1413(2017)32-0046-02

Changes and significance of serum lipoprotein (a) and C-reactive protein in patients with uremic hemodialysis
GAO You, HE Bao-ming, LI Ling-xian
(Department of Laboratory, Hanzhong Central Hospital, Hanzhong 723000, China)

ABSTRACT: Objective To investigate the changes and significance of serum lipoprotein (a) and C reactive protein in patients with uremic hemodialysis. Methods From April 2015 to April 2016, 52 cases patients with uremic hemodialysis admitted in our hospital were selected as the study group, and 52 healthy people with physical examination in our hospital in the same period were selected as the control group. The serum lipoprotein (a) [Lp(a)], C reactive protein (CRP), urea nitrogen and serum creatinine were compared between the two groups. Results After hemodialysis, the levels of serum Lp(a), CRP, urea nitrogen and serum creatinine in study group were obviously higher than those in the control group (P<0.05). After hemo dialysis, the levels of serum Lp(a) and CRP in study group were significantly lower than those before dialysis (P<0.05). In the study group, there was positive correlation between serum Lp(a) and CRP (P<0.05), but no correlation with serum creatinine and urea nitrogen (P>0.05). Conclusion To reduce the occurrence of cardiovascular events, the levels of serum Lp(a) and CRP of patients with uremia should be detected timely, and the treatment should be implemented as soon as possible.

KEYWORDS: uremia; hemodialysis; serum Lp(a); C reactive protein (CRP)

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