血降钙素原在新生儿败血症中的临床价值

马红茹，倪莎莎，吕菊红

（宝鸡市中心医院儿科，陕西 宝鸡，721000）

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摘要：

目的 探讨降钙素原（PCT）对新生儿败血症的诊断、评估感染程度、治疗效果及预后的临床价值。方法 选择我院收治的 NICU 病房确诊为新生儿败血症的84 例（败血症组），同时选择同期住院新生儿局部感染43 例（局部感染组），非感染病例60 例（非感染组），分析PCT 在新生儿败血症中的诊断价值。结果 败血症组患儿血清PCT 水平>10 ng/mL 及0.5～2.0 ng/mL 的比 例高于局部感染组和非感染组，局部感染组0.5~2.0 ng/mL 比例高于非感染组，败血症组患儿血清PCT 水平约0.5 ng/mL 的比 例低于局部感染组和非感染组，局部感染组低于非感染组（P<0.05）；非感染组的CRP 水平>8 mg/L 比例显著低于其他两组（P<0.05）。非感染组的白细胞计数与其他两组比较，差异明显（P<0.05）；败血症组的血培养阳性率为63.10%（53/84）。PCT 及 CRP 诊断新生儿败血症的灵敏度比较，差异显著（P<0.05）。ROC 曲线结果显示，PCT 对新生儿败血症的临床诊断效果优于 CRP。结论 PCT 对新生儿败血症在早期诊断、病情程度判断及治疗效果方面均有重要价值。

关键词：血降钙素原；新生儿败血症；诊断

中图分类号：R722.1文献标志码：A文章编号：2096-1413(2018)02-0046-02

Clinical value of procalcitonin in neontal sepsis


MA Hong-ru, NI Sha-sha, LV Ju-hong
(Pediatrics Department, Baoji Central Hospital, Baoji 721000, China)

ABSTRACT: Objective To discuss the clinical value of procalcitonin (PCT) in the neonatal sepsis diagnosis, assessment of the infectious degree and evaluation therapeutic effect and prognosis. Methods A total of 84 children with neonatal sepsis admitted in the NICU of our hospital were selected (sepsis group), at the same time, 43 cases hospitalized neonates with local infection (local infection group) and 60 cases of non-infected (non-infected group) were selected. The value of PCT in the diagnosis of neonatal sepsis was analyzed. Results The poroportion of PCT> 10 ng/mL and 0.5-2.0 ng/mL in the sepsis group were higher than those of the local infection group and non-infected group, but poroportion of PCT 0.5-2.0 ng/mL in the local infection group were higher than the non-infected group. The poroportion of PCT <0.5 ng/mL in the sepsis group were lower than those of the local other groups, while those in the local infection group was lower than the non-infected group (P<0.05). The proportion of CRP levels> 8 mg/L in the non-infected group was lower than that of the other two groups (P<0.05). Compared with the other two groups, the leukocyte count in the non-infected group was significant (P<0.05); the positive rate of blood culture in the sepsis group was 63.10% (53/84). The sensitivity in the diagnose of neonatal sepsis with PCT and CRP was significant (P<0.05). ROC curve results show that PCT had better clinical diagnosis of neonatal sepsis. Conclusion PCT has great value in the early diagnosis of neonatal sepsis, severity of judgment and treatment.
KEYWORDS: procalcitonin; neonatal sepsis; diagnosis

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